Through its research, education, and service activities, BCBI is involved with development and application of informatics and data science approaches across the full spectrum of biomedicine and health care (translational bioinformatics, clinical research informatics, clinical informatics, consumer health informatics, public and population health informatics, global health informatics, and biomedical data science). 

Areas of methodological expertise include: biological sequence analysis; data extraction, integration, management, and analysis; data mining, machine learning, and deep learning; clinical decision support; evaluation; human factors engineering; information retrieval; knowledge engineering; natural language processing and text mining; privacy and security; and, software engineering and system development.

As part of transdisciplinary collaborations, these methods are being applied to support artificial intelligence in health care, clinical and translational research, and learning health systems. Specific health contexts include: cancer, cardiovascular conditions, infectious diseases, maternal and child health, and mental health.